Document Details

Document Type : Article In Journal 
Document Title :
EVALUATION OF TRANSFORMING GROWTH FACTOR ALPHA (TFG-a) IMMUNOREACTIVITY IN SOME BENIGN AND MALIGNANT SALIVARY GLAND TUMORS
EVALUATION OF TRANSFORMING GROWTH FACTOR ALPHA (TFG-a) IMMUNOREACTIVITY IN SOME BENIGN AND MALIGNANT SALIVARY GLAND TUMORS
 
Document Language : English 
Abstract : Transforming Growth, Factor Alpha (TGP-a) is expressed in both normal and malignant epi- thelial cells. Although the expression of TGF-a has been extensively studied in some human epi- thelial neoplasms, few reports have been published concerning its expression in salivary gland tu- mors. The aim of this work is to study the immunological presence of TGF-a in benign and malignant salivary gland tumors. The present work was curried out on 27 biopsies of salivary gland tumors divided as follow: pleomorphic adenoma (6), adenolymphoma (4), malignant pleomorphic adenoma (4), adenoidcystic carcinoma (6), mucoepidermal carcinoma (4) and acinic cell carcinoma (3). Five biopsies of normal salivary gland tissues were included as controls. All cases were ex- amined immunohistochemically using a monoclonal anti-TGF-a antibody. The results showed weak to negative reaction in the benign tumors and moderate to strong staining in the malignant ones. The over expression of TGF-a in malignant salivary gland tumors may represent an underlying mech- anism of the development and progression of these tumors. 
ISSN : 0 
Journal Name : Egyptian Dental Journal 
Volume : 4 
Issue Number : 1 
Publishing Year : 1424 AH
2004 AD 
Article Type : Article 
Added Date : Monday, May 5, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زينب درويشDarwish, Zeinab ResearcherDoctoratezdarweesh@kau.edu.sa

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